Manual de Exames


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ASPARTATO AMINOTRANSFERASE - TGO

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Soro

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Determinação de dano celular do parênquima hepático; marcador auxiliar de infarto agudo do miocárdio e pericardite. A TGO é principalmente originada a partir do coração, fígado, musculatura esquelética, rins, pâncreas, baço, pulmão. Valores muito elevados sugerem hepatites ou outras formas de necrose hepatocelular, podendo ser encontrados em tumores necróticos grandes ou hipóxia, insuficiência congestiva e choque. Elevações de TGO não explicadas devem ser investigadas. Valores aumentados: doenças hepáticas [necrose ativa do parênquima (ex. viroses hepatoespecíficas e não hepatoespecíficas com acometimento hepático), doença biliar extrahepática, congestão, insuficiência cardíaca, cirrose, obstrução biliar, neoplasia primária ou metastática, granulomas, isquemia hepática, eclampsia, drogas hepatotóxicas], doenças músculo esqueléticas (injeções intramusculares, mioglobinúria), infarto agudo do miocárdio, pancreatite aguda, dano intestinal (ex. cirurgia, infarto), infarto pulmonar, infarto cerebral, neoplasmas cerebrais, infarto renal, queimaduras, intoxicações, anemias hemolíticas, distrofia muscular de Duchenne, trauma, choque, hipotireoidismo. Valores diminuídos: azotemia, diálise renal crônica, estados de deficiência de piridoxal fosfato (ex. desnutrição, gravidez, doença hepática alcoólica). Valores normais: angina pectoris, insuficiência coronariana, pericardite. Interferentes: stress muscular +, heparina +, salicilatos +, opiáceos +, tetraciclinas +, isoniazida +, lipemia +, hemólise +, oxacilina +, ampicilina +, uremia -, metronidazol -, progesterona +, esteróides anabolizantes +.

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