Manual de Exames


Letra I


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INTERLIGADORES C-TERMINAIS DO COLAGENO TIPO I

Material:

Soro

Instruções de coleta:

Coletar em tubo sem anticoagulante. Separar o soro. Enviar Congelado.

Informações:

Os telopéptideos terminal C (Ctx) são fragmentos de colagénio de tipo I especialmente importantes. Nos telopéptidos terminal C, o ácido aspártico presente transforma-se na forma-Ä do ácido aspártico à medida que o osso vai envelhecendo (Ä-CTx).Niveis elevados sao encontrados em criancas, pacientes com osteoporose, osteomalacia, osteodistrofia renal, em uso de corticoide, Doenca de Paget, hiperparatireoidismo e hipertireoidismo. Recomenda-se a determinação dos telopéptidos terminal C para monitorização da eficácia da terapêutica anti-reabsorção (p. ex., bifosfonato ou terapêutica hormonal de substituição) na osteoporose ou em outras doenças ósseas. Desta forma, as alterações induzidas pela terapêutica podem ser demonstradas ao fim de apenas algumas semanas. Bibliografia: Bonde M, Qvist P, Fledelius C, Riis BJ, Christiansen C. Immunoassay for Quantifying Type I Collagen Degradation Products in Urine Evaluated. Clin Chem 1994;40(11):2022-2025. Fledelius C, Johnsen A, Cloos P, Bonde M, Qvist P. Identification of a Ä-isomerized aspartyl residue within the c-terminal telopeptide ~1 chain of type I collagen. Possible relation to aging of bone. J Bone Miner Res 1996;11(Suppl.1) Abstract No 113. Rosenquist C, Fledelius C, Christgau S, Pedersen BJ, Bonde M, Quist P, et al. Serum CrossLaps One Step ELISA. First application of monoclonal antibodies for measurement in serum of bone-related degradation products from C-terminal telopetides of type I collagen. Clin Chem 1998; 44(11):2281-2289. Seibel MJ. Biochemische Marker des Knochenstoffwechsels: Klinische Wertigkeit in der Praxis. Ther Umsch 1998;55(11):676–684.

Referência:

  • mulher:
  • pré menopausa : 0,025 - 0,573 ng/mL
  • pós menopausa : 0,106 - 1,008 ng/mL
  • homem :
  • 30-50 anos : 0,016 - 0,584 ng/mL
  • 51-70 anos : 0,000 - 0,704 ng/mL
  • > 71 anos : 0,000 - 0,854 ng/mL
 

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